When Kōichi Sasakibara transfers to his new school, he can sense something frightening in the atmosphere of his new class, a secret none of them will talk about. At the center is the beautiful girl Mei Misaki. Kōichi is immediately drawn to her mysterious aura, but then he begins to realize that no one else in the class is aware of her presence.
Senō Natsuru is your normal, everyday high school student. However, he's been chosen to be a Kämpfer, who's objective consists on fighting other Kämpfer with either guns, swords or magic. However, there's catch—first, you can't chose if you're a Kämpfer or not, and second, you must have the body of a girl to use your powers.
Panty and Stocking—the Anarchy Sisters—are two nasty-ass angels who got booted from the pearly gates for being foul-mouthed bitches! Now they spend their nights blowing up ghosts in the seedy abyss between Heaven and Earth. Panty likes sex, Stocking likes sweets, their afro-sporting main man Garter Belt has a fetish we can't mention. Together, they're turning the mean streets of Daten City into a buffet of bodily fluids. Ghosts don't stand a chance against their lingerie of mass destruction, and if this debaucherous duo can collect enough Heaven Coins, they just might get their halos back. It's a slim chance in hell, but anything can happen when you're rolling commando, especially with Panty and Stocking!