Kamijou Touma is a student living in Academy City, a highly advanced place in terms of technology. Despite being gauged as a level zero esper (no powers), he possesses on his right hand the Imagine Breaker, an ability that negates any power whatsoever. Touma finds a young girl named Index who is trying to run away from Necessarius, a powerful magic organization that she is member of. Blessed with the skill of memorizing any sort of information, she holds 103,000 forbidden magical books within her head. As science and magic cross paths, Touma must face several dangers amid espers and magicians who appear at the exciting scientific town.
Index is still a fugitive and many powerful magical organizations and individuals want to take her to use the books in her memory, eliminating her in the process. War between those organizations is also starting to emerge. Index can only rely on her friend Tōma, who has always protected her, along with Misaka and other friends from the Academy.
In a world after death, angels fight for their fate and their future. Yuri, the leader of the Shinda Sekai Sensen, rebels against the god who destined her to have an unreasonable life. On the otherhand, Tenshi, the chairperson of the student council for the world after death, battles against the SSS members. SSS members utilize armed weaponry to battle it out against the angels harnessing supernatural powers.
Shirou Emiya lost his parents in a fire when he was young and was later adopted by a sorceror by the name of Kiritsugu Emiya. Although he was full of admiration for his adopted father and yearns to become an ally of justice, Shirou has limited powers and was unable to become a strong sorceror like his father. That is until one fateful day, he was drawn into the Holy Grail War and had to summon a female "Servant" known as Saber in order to protect himself. It turns out that the Holy Grail War involves a series of battles among powerful sorcerors to fight for the possession of a relic that will grant one's wishes, the Holy Grail. There are altogether seven "Masters" who can summon their respective "Servants" from different classes known as Saber, Archer, Rider, Berserker, Lancer, Caster and Assasin. These "Servants" have to hide their names in order not to reveal their weaknesses to the enemies. The story revolves around Shirou and his entanglement in the Holy Grail War.
Ten years ago, the magus Kiritsugu Emiya saved one lone survivor of a great disaster. As he cried in happiness, he proclaimed that by saving him, he had saved himself. The boy swore then that he would become a hero who lived to save others. Five years after the death of his foster father, Shirō Emiya finds himself drawn into a battle to the death between seven magi called Masters, where each commands the spirit of a hero of legend called a Servant in pursuit of having one wish granted by the legendary Holy Grail. In this battle, Shirō will finally have the chance to face the ghosts of his past, and to find his path to face his dreams and his future. Through the power of the Holy Grail, his wish will finally come true, for a hero of justice must have an evil to defeat.
The year is 1939 - it was then that the Neuroi appeared. Nobody knows where they came from or what their ultimate agenda is, but the fact remains that their attacks drove people out of their towns and cities. In order to take arms against them, humanity develops a new anti-Neuroi weapon called the "Striker Unit." Using the power of magic to fight against the monsters, this new device enhances and amplifies the power of female magic-wielders. To use this device, young witches from all over the world have been brought together to form an elite task force unit called the 501st Joint Fighter Wing, commonly known as the "Strike Witches."