Two brothers lose their mother to an incurable disease. With the power of "alchemy", they use taboo knowledge to resurrect her. The process fails, and as a toll for using this type of alchemy, the older brother, Edward Elric loses his left leg while the younger brother, Alphonse Elric loses his entire body. To save his brother, Edward sacrifices his right arm and is able to affix his brother's soul to a suit of armor. With the help of a family friend, Edward receives metal limbs - "automail" - to replace his lost ones. With that, Edward vows to search for the Philosopher's Stone to return the brothers to their original bodies, even if it means becoming a "State Alchemist", one who uses his/her alchemy for the military.
To find a way in rescuing Pokota's country Taforashia which was sealed by Rezo, Lina and her group are in search for the Hellmaster's jar in what the Red Priest placed his soul after death. Zelgadis is willing to do anything to get the jar for changing back into a human while Zuuma is plotting on revenge and accomplishing assignment in killing Lina Inverse. Still a big mystery for her and the others is what Xellos is aiming for in this battle.