The story centers around Akamatsu Yuuki, a boy who joins the staff of his school's second newspaper. The editor-in-chief Nikaidou Ayaka immediately assigns him to the life (Jinsei) advice column. Three girls — the science representative Endou Rino, the liberal arts representative Kujou Fumi, and the physical education representative Suzuki Ikumi — answer requests from students about whatever is troubling them.
Tokiha Mai and her sickly younger brother, Takumi, have received a scholarship to attend the prestigious Fuuka Academy. On the way, the ferry they are travelling on becomes the site of a destructive battle between two girls wielding apparently supernatural powers. This is only the beginning of their troubles, as Mai learns that she herself possesses these powers - the powers of a HiME.
An art club in a certain middle school has the following members: Subaru Uchimaki, who is a genius at drawing faces, but only wants to draw the perfect 2D wife; Colette, a rich troublemaker who never stops making mischief; and the club president, who sleeps through sessions and collects sleeping aids. Mizuki Usami is the only person in the club who wants to do art club-like activities, and constantly struggles to do so.