Goku is back with his new son, Gohan, but just when things are getting settled down, the adventures continue. Whether he is facing enemies such as Frieza, Cell, or Buu, Goku is proven to be an elite of his own and discovers his race, Saiyan and is able to reach Super Saiyan 3 form. He meets many new people, gaining allies and well as enemies, as he still finds time to raise a family and be the happy-go-lucky Saiyan he is.
Two brothers lose their mother to an incurable disease. With the power of "alchemy", they use taboo knowledge to resurrect her. The process fails, and as a toll for using this type of alchemy, the older brother, Edward Elric loses his left leg while the younger brother, Alphonse Elric loses his entire body. To save his brother, Edward sacrifices his right arm and is able to affix his brother's soul to a suit of armor. With the help of a family friend, Edward receives metal limbs - "automail" - to replace his lost ones. With that, Edward vows to search for the Philosopher's Stone to return the brothers to their original bodies, even if it means becoming a "State Alchemist", one who uses his/her alchemy for the military.
Set in the Shinigami technical school for weapon meisters, the series revolves around 3 groups of each a weapon meister and a human weapon. Trying to make the latter a "Death Scythe" and thus fit for use by the Shinigami, they must collect the souls of 99 evil humans and 1 witch.