In an alternate world, the Cold War has continued to persist for 140 years. As a result, the world was divided into two factions: the West Block, and the East Block. As the Cold War drags on, the tension between the two factions, as well as the amount of nuclear weapons they have, rise. Mylene Hoffman is a female cyborg who is a spy for the West Block. Together with three other agents, Mylene partakes in various missions issued by her superiors.
Blood Lad follows Staz, a vampire that is obsessed with the human world, and Fuyumi, a human girl that was killed and turned into a ghost after wandering into the demon world. Staz promises to help Fuyumi regain her humanity by bringing her back to life, as it means that he would be able to visit the human world
Spike Spiegel, a bounty Hunter with a dark past, lives on bounty to bounty, barely making it each time, or not making it at all. His partners Jet Black, Faye Valentine, Ed and Ein the dog all help him in his adventures from planet to planet.
Hotaro Oreki doesn't like to do things that he considers a waste of energy. However, things start to change when he enters high school because even though he does not want to join any non-compulsory school activities, his older sister requested that he join the memberless Classic Literature Club so that it won't get abolished. Unbeknownst to him, another student, Eru Chitanda, already planned to join; but instead of being free from club obligations, Hotaro eventually joined as he is strangely unable to refuse or escape from Eru's passionate gaze of curiosity. Together with his friends Satoshi and Mayaka, they began to discuss a variety of mysteries in school that only H?tar? seems to be able to solve, including the mystery that lingered on from Eru's childhood memory.
Misaki Ayuzawa is the first female student council president at a once all-boys school turned co-ed. She rules the school with strict discipline demeanor. But she has a secret—she works at a maid cafe due to her families circumstances. One day the popular A-student and notorious heart breaker Takumi Usui finds out her secret and makes a deal with her to keep it hush from the school in exchange for spending some time with him.
Gene Starwind and his partner Jim Hawking run a small business on the backwater planet of Sentinel III. But all that changes the day that Hilda hires them for a bodyguard job. Now, thrust into a mystery they don't fully understand, they're on the run from the cops, the pirates, an angry alien, and a mysterious assassin. But they've got one thing going in their favor—they have the galaxy's most advanced ship, the Outlaw Star.
Mugen is a fierce animal-like warrior with a unique Bboying (break-dance) inspired fighting style. Jin has a more traditional style but don’t think of this as a weakness because his skills are amazing. The two contrasting samurai warriors are far from friends, yet their separate paths seem to cross anyways. Mugen is wandering aimlessly through the city when he stumbles upon a teahouse where he meets Jin and Fuu (A ditzy waitress, but don‘t think she doesn‘t have anything hidden up her sleeves). Fuu convinces them both to come with her in search of a mysterious samurai that smells like sunflowers and their journey begins. This modernized hip-hop tale breaks the barriers of the common, historical, samurai anime.
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Space Dandy is a space hunter, someone who is paid to search for new, undiscovered alien species. It's an industry where the prize goes to the person who finds aliens the fastest. Dandy searches unknown planets for strange beings with his companions, QT the worn-out robot and Meow from Betelgeuse. Meanwhile, they're being chased by minions of the Gogol Empire, for reasons that are still a mystery.