Nayu shocks her schoolmates on the first day of middle school by wearing black lace panties. She aims to ''spread the word on the merits of underwear'', and help other girls concerned with their development - by opening a underwear club.
The Japanese Ministry of Defense has an anti-paranormal special forces group called the Paranormal Disaster Countermeasure Headquarters. They're the ones responsible to protect Japanese soil and its people from supernatural and paranormal events. However, things didn't go so well in one of their missions, which leads to intervention by the Ministry of Enviroment's Supernatural Disaster Countermeasures Division after the PDCH has sustained large numbers of casualties battling demons.
Asano begins work as the housekeeper for the old family of Shimazu, where he meets the ill-mannered, selfish, beautiful Sakaya. She is actually the 37th head of the Shimazu family in charge of sealing away monsters with Spirit Archery. Discovering that he has the powers of "true names" and "true eyes,"Asano becomes wrapped up in Sakaya's battle with the monsters as her assistant.
Tokiha Mai and her sickly younger brother, Takumi, have received a scholarship to attend the prestigious Fuuka Academy. On the way, the ferry they are travelling on becomes the site of a destructive battle between two girls wielding apparently supernatural powers. This is only the beginning of their troubles, as Mai learns that she herself possesses these powers - the powers of a HiME.
A girl named Mitsuki Kanzaki lives with her step-brother Yuya after her mother remarries. One day, Mitsuki is possessed by the self-proclaimed spirit of a young girl, Hiyori Kotobuki. Hiyori (in Mitsuki's body) must fall in love with Yuya to move toward the "Gates of Heaven."
In Oshima the happy, carefree 14-year-old Akane Isshiki lived a poor but well-loved life together with her reliable little sister, Momo, who does all the housework, and her grandfather, Kenjirō, a genius inventor who only created useless devices. When the weather is clear, they can see the artificial island, Blue Island, across the sea. In the center of that island rises the revolutionary Manifestation Engine, a discovery that solved the world's energy problems, and leads to some major problems.