Seven schools are constantly "at war" with each other, and the students within—both male and female—have become skilled fighters and constantly battle with rival schools. Their lives and fates are guided by strange jewels that contain the spirits and destinies of warriors from the Sangokushi period. One girl, Sonsaku Hakufu, has recently moved to Japan and is apparently destined to unite the schools as her counterpart united seven countries long ago. But, like all heroes, there is a darker side to her fate, and as always there is a constant struggle by those around her to break the chains of their own destinies and make their own lives.
WIXOSS is a card game that's popular with teenagers. Supposedly there exist "LRIG Cards," female character cards with wills of their own. Special girls can hear the voices of the LRIGs, and those who possess them are called "Selectors." These Selectors have card battles in a dimension that other humans cannot access. It's said that whoever triumphs in these battles will have their wish granted. Ruko Kominato is the latest girl to find a LRIG card. She names hers Tama, and without any further explanation is thrown into her life as a Selector.
In the remote Southern Cross island, a secret organization named The Glittering Crux plans to reactivate giant mobile suits that have been sealed for ages. Known as cybodies, they can only be controlled by pilots identified as star drivers. To unleash their full power, the mysterious group must brake the seals of the four shrine maidens that reside in the isle. Recently arrived outsider Takuto Tsunashi vows to stop the Glittering Crux in order to protect Wako Agemaki, girl who saved his life and is one of the four maidens. Wako is a lively young lady who has already been betrothed to Sugata Shindou, a rich and talented childhood friend. Despite being very close to Agemaki, Sugata quietly disapproves this engagement since it was forced on to them due to a family tradition. The melancholic couple becomes a radiant trio as Takuto becomes not only their friend, but protector of the seals since he is none other than the Galactic Pretty Boy, gifted star driver of Tauburn, the 22nd cybody.
Ten years after the Ceremonial Battle, a teenage boy named Yuuki Judai heads off in order to join the Duelist Yousei School located on a remote island off the coast of Japan. There he meets his fellow students and gains a few friends, along with a few enemies. Judai is put into the lowest rank of Osiris Red, but he continues to test his skills against the students and faculty to prove his worth as a Yousei Duelist and earn the respect of everyone around him.