Godō Kusanagi is a 16-year-old high school boy, who once killed the god "Verethragna" and acquired the title of "Campione" ("God Killer") when he was 15. Erica Brandelli is a 16-year-old Italian girl, who is a "Great Knight" of the magic society "Bronze Black Cross" and had fought together with Godo to defeat Verethragna. Godo doesn't like fighting but his title of "Campione" makes him get involved in battles against other Campiones and uncontrollable gods.
Takato Matsuda, Ruki Matsuno, and Lee Jenrya are children who have, by fate, recieved real Digimon, unlike the imaginary ones in the card game they play. Each of the children, or "Digimon Tamers", have their different views on how Digimon should be treated. But when other Digimon begin to appear around Japan, they must put aside their differences to fend off the digital intruders; even though Yamaki, who is the head of a secret organization called Hypnos is trying to eliminate all of the Digimon himself.
"Mob" is a boy who will explode if his emotional capacity reaches 100%. This boy with psychic powers earned his nickname "Mob" because he does not stand out among other people. He keeps his psychic powers bottled up so he can live normally, but if his emotional level reaches 100, something will overwhelm his entire body.
A new semester has arrived for Tsukune and the gang featuring a handfull of girl obsessed female first years and it seems like among these first years emerges another vampire who holds a grudge against her sister Moka. What shall this grudge lead to in the future and shall Tsukune suceed in taming this new problem child into his friend, no one knows what the future holds.
The Yūki's residence is now full of people: in addition to Rito and Mikan Yūki, Lala, her twin sisters Nana and Momo, and Golden Darkness. Momo, who also falls for Rito, actively tries to create a harem for him. Meanwhile, a mysterious red hair girl named Mea Kurosaki enters Sainan High School with a hidden agenda.
K?sei Arima was a piano prodigy until his mother died when he was eleven years old. The shock of losing her made him lose any interest in piano, and his life has felt monotonous ever since. Then, when he's fourteen, his childhood friend Tsubaki introduces him to her classmate Kaori, a free-spirited violinist. Her enthusiasm reignites his interest in music and in life.