In 2046, people can access a virtual network known as the Neurolinker via their cellphone terminals. A perpetual victim of bullying, middle school student Haruyuki spends his time absorbed in games in a corner of his local network. One day he is approached by the most famous girl in his school, Kuroyukihime (Black Snow Princess). She gives him a strange program called Brain Burst that has the power to "accelerate the world."
Two brothers lose their mother to an incurable disease. With the power of "alchemy", they use taboo knowledge to resurrect her. The process fails, and as a toll for using this type of alchemy, the older brother, Edward Elric loses his left leg while the younger brother, Alphonse Elric loses his entire body. To save his brother, Edward sacrifices his right arm and is able to affix his brother's soul to a suit of armor. With the help of a family friend, Edward receives metal limbs - "automail" - to replace his lost ones. With that, Edward vows to search for the Philosopher's Stone to return the brothers to their original bodies, even if it means becoming a "State Alchemist", one who uses his/her alchemy for the military.
A short flashback of what happened in prequel of Heaven's Lost Property series until there's an Angel, Hiyori Kazane who is dreaming while her real body is in heaven. She had a crush on the main protagonist, Tomoki Sakurai who fight until the end where the world has memory about Hiyori erased when she died in her dream and returned to her real body. She wanted to return to her dream so much that she got modified into an Angeloid of Clockwork by heaven's master but got back consciousness with help of Tomoki. However, it was not enough to save her life.