Akihito Kanbara is a high school sophomore in the literature club who believes himself to be a "Meganest", and although he appears to be human, he is actually half Yōmu, which makes him invulnerable to wounds, due to the fact that he can heal so quickly, and also immortal. One day, Akihito meets freshman Mirai Kuriyama when it appears as if she is about to attempt suicide by jumping off of the school rooftop. Mirai is isolated because of her ability to manipulate blood, which is considered heresy even among other members of the underworld, so she is shunned. Soon after Akihito saves Mirai, disturbing events begin to arise.
Special abilities occur among a small percentage of boys and girls in puberty. Yū Otosaka uses his power without others knowing, and lives a fairly normal, average school life. Before him suddenly appears a girl, Nao Tomori. Due to his meeting with her, the fate of special power-users will be exposed.
In Tokyo, an impenetrable field known as "Hell's Gate" appeared ten years ago. At the same time, psychics who wield paranormal powers at the cost of their conscience also emerged. Hei is one of the most powerful of these psychic agents, and along with his blind associate, Yin, works for one of the many rival agencies vying to unlock the mysteries of Hell's Gate.
"Minimum" - a special inborn power found in a limited number of human beings, known as "minimum holders." In Yokohama, the detective team Hamatora, formed by two minimum holders named Nice and Murasaki, comes across information connected to a serial killer being pursued by their old friend Art. It turns out all the victims are minimum holders like them. Unwillingly at first, the two detectives become involved in the investigation.
An art student named Jin Mikuriya carves a statue from the wood of the Kannagi tree only to have the statue come to life in the form of a goddess, who has now taken over the statue. He and "Nagi" work together to destroy the impurities that are gathering in the town.
Tokiha Mai and her sickly younger brother, Takumi, have received a scholarship to attend the prestigious Fuuka Academy. On the way, the ferry they are travelling on becomes the site of a destructive battle between two girls wielding apparently supernatural powers. This is only the beginning of their troubles, as Mai learns that she herself possesses these powers - the powers of a HiME.
High school sophomore Yuki Hase noticed that Kaori Fujimiya, his classmate, was always alone. He tried to start a conversation with her but was turned down: "My memories of friendship can last only a week," she said. Despite of knowing this shocking truth, Yuki keeps trying to be Kaori's "new" friend every week.
In a future world where an organization called the GGP has taken control of the world, Rin Ogata was a promising up-and-comming ballet dancer, but suffered a serious injury and decided to quit. Years later in college she comes across a club building and soon finds herself intrigued by a transforming motorcycle like vehicle called a Rideback. She discovers that her unique ballet skills with balance and finesse make her a born natural on a Rideback. However, those same skills also get her into serious trouble with the government.
Takeya Yuki is in love with the school. For her, it's a wonderful place, where she enjoys her school activities, especially the activities of her club: School Life Club. The club has Rii-chan as the president, Kurumi-chan as another member, and the teacher, Megu-nee, always there for them. Yes, she is in love with her school... in her mind. Because, for her, the reality of the school and their club's activities is way too hard to be perceived...