Naota is a normal Japanese 6th grade boy (although a little cynical), but when his older brother leaves for America to play baseball, his brother leaves his 17 year old girlfriend Mamimi behind. Mamimi is sending mixed signals and advances to Naota, and he doesn't know what to do about her. But to make matters worse, Naota's world is totally turned upside down when he is run over by a woman on a Vespa. During their first encounter, she hits him over the head with her guitar, which then causes a horn to grow out of his forehead. She calls herself "Haruko" and her presence changes Naota's life to even further insanity.
In Osaka in the year "AD20XX," Hand Shakers are partners who can summon "Nimrodes," weapons born from their deep psyche by joining hands. In order to grant the pair's wish, the Hand Shakers compete with and fight other Hand Shaker pairs. The top pair will then meet and challenge "God."
"Mob" is a boy who will explode if his emotional capacity reaches 100%. This boy with psychic powers earned his nickname "Mob" because he does not stand out among other people. He keeps his psychic powers bottled up so he can live normally, but if his emotional level reaches 100, something will overwhelm his entire body.
Panty and Stocking—the Anarchy Sisters—are two nasty-ass angels who got booted from the pearly gates for being foul-mouthed bitches! Now they spend their nights blowing up ghosts in the seedy abyss between Heaven and Earth. Panty likes sex, Stocking likes sweets, their afro-sporting main man Garter Belt has a fetish we can't mention. Together, they're turning the mean streets of Daten City into a buffet of bodily fluids. Ghosts don't stand a chance against their lingerie of mass destruction, and if this debaucherous duo can collect enough Heaven Coins, they just might get their halos back. It's a slim chance in hell, but anything can happen when you're rolling commando, especially with Panty and Stocking!
Set in the Shinigami technical school for weapon meisters, the series revolves around 3 groups of each a weapon meister and a human weapon. Trying to make the latter a "Death Scythe" and thus fit for use by the Shinigami, they must collect the souls of 99 evil humans and 1 witch.