During the Prohibition era, in the Lawless district the law has no power, the mafia rule the streets, and the illegally made liquor flows freely. At one time Avilio lived in this district, but after a mafia dispute ended in the murder of his family, he went into hiding. Later, Avilio receives a letter from a mysterious person that ignites his passion for revenge and leads him to return to Lawless. There, he infiltrates the Vanetti family and gets close to Nero.
In Osaka in the year "AD20XX," Hand Shakers are partners who can summon "Nimrodes," weapons born from their deep psyche by joining hands. In order to grant the pair's wish, the Hand Shakers compete with and fight other Hand Shaker pairs. The top pair will then meet and challenge "God."