Akihito Kanbara is a high school sophomore in the literature club who believes himself to be a "Meganest", and although he appears to be human, he is actually half Yōmu, which makes him invulnerable to wounds, due to the fact that he can heal so quickly, and also immortal. One day, Akihito meets freshman Mirai Kuriyama when it appears as if she is about to attempt suicide by jumping off of the school rooftop. Mirai is isolated because of her ability to manipulate blood, which is considered heresy even among other members of the underworld, so she is shunned. Soon after Akihito saves Mirai, disturbing events begin to arise.
Tokiha Mai and her sickly younger brother, Takumi, have received a scholarship to attend the prestigious Fuuka Academy. On the way, the ferry they are travelling on becomes the site of a destructive battle between two girls wielding apparently supernatural powers. This is only the beginning of their troubles, as Mai learns that she herself possesses these powers - the powers of a HiME.
After experiencing a bizarre dream, Madoka Kaname, a kind 14-year-old girl, encounters a magical creature named Kyube. Madoka and her friend Sayaka Miki are offered the opportunity of gaining magical powers if they agree to make a contract with the strange little being. He will also grant them one wish, but in exchange they shall risk their lives by accepting the responsibility of fighting witches. Invisible to human eyes, witches are catalysts of despair in the areas they inhabit. An ally of Kyube, a magical girl named Mami Tomoe, befriends and encourages the two girls to accept the contract. For an unknown reason, another magical girl named Homura Akemi is determined to prevent Madoka from accepting the deal.
WIXOSS is a card game that's popular with teenagers. Supposedly there exist "LRIG Cards," female character cards with wills of their own. Special girls can hear the voices of the LRIGs, and those who possess them are called "Selectors." These Selectors have card battles in a dimension that other humans cannot access. It's said that whoever triumphs in these battles will have their wish granted. Ruko Kominato is the latest girl to find a LRIG card. She names hers Tama, and without any further explanation is thrown into her life as a Selector.
Dating sim master Keima Katsuragi wants nothing more than to immerse himself in the 2D world, chasing digital girlfriends. But when the so-called "Capturing God" answers a mysterious email from an unknown sender, Keima finds himself chasing down real-life ladies in an attempt to help the peppy demon Elsie de Lute Irma capture "lost souls" escaped from the depths of hell. Now, lest the explosive collar around his neck detonate, Keima must convince various girls to fall in love with him in order to scare out the souls hiding in their hearts.
Ken Kaneki is a bookworm college student who meets a girl names Rize at a cafe he frequents. They're the same age and have the same interests, so they quickly become close. Little does Kaneki know that Rize is a ghoul - a kind of monster that lives by hunting and devouring human flesh. When part of her special organ - "the red child" - is transplanted into Kaneki, he becomes a ghoul himself, trapped in a warped world where humans are not the top of the food chain.
After moving into the quiet town of Hinamizawa, Maebara Keiichi spends his days blissfully in school often playing games with his local friends. However, appearances can be deceiving. One fateful day, Keiichi stumbles upon news of a murder that had occurred in Hinamizawa. From this point on, horrific events unfold in front of Keiichi, as he soon learns his close friends may not be all that they seem. Based on the amateur mystery game by 07th Expansion, the story is told in a series of different scenarios.