In an alternate world, the Cold War has continued to persist for 140 years. As a result, the world was divided into two factions: the West Block, and the East Block. As the Cold War drags on, the tension between the two factions, as well as the amount of nuclear weapons they have, rise. Mylene Hoffman is a female cyborg who is a spy for the West Block. Together with three other agents, Mylene partakes in various missions issued by her superiors.
In Tokyo, an impenetrable field known as "Hell's Gate" appeared ten years ago. At the same time, psychics who wield paranormal powers at the cost of their conscience also emerged. Hei is one of the most powerful of these psychic agents, and along with his blind associate, Yin, works for one of the many rival agencies vying to unlock the mysteries of Hell's Gate.
The Diclonius, a mutated homo sapien that is said to be selected by God and will eventually become the destruction of mankind, possesses two horns in their heads, and has a "sixth sense" which gives it telekinetic abilities. Due to this dangerous power, they have been captured and isolated in laboratories by the government. Lucy, a young and psychotic Diclonius, manages to break free of her confines and brutally murder most of the guards in the laboratory, only to get shot in the head as she makes her escape. She survives and manages to drift along to a beach, where two teenagers named Kouta and Yuka discovers her. Having lost her memories, she was named after the only thing that she can now say, "Nyuu," and the two allow her to stay at Kouta's home. However, it appears that the evil "Lucy" is not dead just yet...
The series takes place in the near future, when it is possible to instantaneously measure and quantify a person's state of mind and personality. This information is recorded and processed, and the term "Psycho-Pass" in the anime's title refers to a standard used to measure an individual's being. The story centers around the "enforcement officer" Shinya Kōgami, who is tasked with managing crime in such a world.
Sotobamura is a small village with around 1300 residents; so small the village isn't even connected to a single highway. An isolated village in which old customs, such as the burial of the dead, are still practiced. One day, the bodies of three people are found dead. Although Ozaki Toshio, the village's lone doctor, feels uncertain, he treats the deaths as a normal occurrence. However, in the days following, the villagers start to die one after the other.
In a world where dead people turn into books and are stored in the Bantorra Library where anyone who reads a book can learn their past. Bantorra Library is maintained by Armed Librarians who wield psychic powers and their enemy is a religious society known as Sindeki Kyōdan.
Yukiteru (Yuki) Amano is a loner who never really interacts with people and prefers writing a diary on his cell phone, with his only companion being an imaginary friend named Deus Ex Machina, the God of Time and Space. However, Yuki soon learns that Deus is not a figment of his imagination but real when Deus makes him a participant in a battle royale with eleven others. Within this "Diary Game", the contestants are given special diaries that can predict the future, with each diary having unique features that gives it both advantages and disadvantages.