Kamijou Touma is a student living in Academy City, a highly advanced place in terms of technology. Despite being gauged as a level zero esper (no powers), he possesses on his right hand the Imagine Breaker, an ability that negates any power whatsoever. Touma finds a young girl named Index who is trying to run away from Necessarius, a powerful magic organization that she is member of. Blessed with the skill of memorizing any sort of information, she holds 103,000 forbidden magical books within her head. As science and magic cross paths, Touma must face several dangers amid espers and magicians who appear at the exciting scientific town.
Index is still a fugitive and many powerful magical organizations and individuals want to take her to use the books in her memory, eliminating her in the process. War between those organizations is also starting to emerge. Index can only rely on her friend Tōma, who has always protected her, along with Misaka and other friends from the Academy.
Mikoto Misaka, one of the strongest Level 5 espers in Academy City, gave her DNA map to a certain doctor when she was young, believing that it may be used for greater good. Unfortunately for her, it ended up being used to create countless clones of herself; forming the Misaka network, in order to create the strongest esper by sacrificing these clones whom she considers as her own sisters.
Season Fairies create and control the weather using special musical instruments. They make the wind blow, the snow fall, the sun shine; if it's something weather related, they are the ones who make it happen. Sugar, an apprentice Snow Fairy, and her friends Salt and Pepper, all want to become full-fledged Season Fairies, and the only way to achieve this is to search for and find the "Twinkles" that will make their magical flowers bloom. The only problem is that none of them have any idea what a Twinkle is. They enlist the somewhat unwilling help of Saga, a human girl who can see Season Fairies. Much to her annoyance, Saga's perfectly planned and ordered life has just become a little too lively for her taste. Together, they search for the mysterious Twinkles while trying to perfect their magic.
In Tokyo, an impenetrable field known as "Hell's Gate" appeared ten years ago. At the same time, psychics who wield paranormal powers at the cost of their conscience also emerged. Hei is one of the most powerful of these psychic agents, and along with his blind associate, Yin, works for one of the many rival agencies vying to unlock the mysteries of Hell's Gate.
Sai Akuto aims to become part of his country's highest order of magicians and contribute to society as one of its clergy. On the day he is admitted into the Constan Magical Academy, his aptitude test predicts the following though: "Future Occupation... Devil King". Thus begins his difficult school life in which he is resented by the combative female class head, Hattori Junko, desired by a girl with mysterious powers, Soga Keena, and guarded by a beautiful female android, Korone.
Takato Matsuda, Ruki Matsuno, and Lee Jenrya are children who have, by fate, recieved real Digimon, unlike the imaginary ones in the card game they play. Each of the children, or "Digimon Tamers", have their different views on how Digimon should be treated. But when other Digimon begin to appear around Japan, they must put aside their differences to fend off the digital intruders; even though Yamaki, who is the head of a secret organization called Hypnos is trying to eliminate all of the Digimon himself.
In a far distant future, humanity has embraced the Fractale system as the ultimate path towards utopia. Comprised of several trillion networked computers, Fractale was created in the 22nd century to promote a peaceful lifestyle for the entire world in exchange of a periodic recovery of personal data from individuals through terminals located within their bodies. Living in a rocky coast region, Clain is a young boy fascinated by old technology. After helping a girl named Phryne, she gives him a pendant before disappearing by the next morning. Accessing the data from the peculiar gift, Clain ends up summoning a girl-shaped avatar named Nessa. Together they start a journey as they discover the truth behind the Fractale system.
In the crime-ridden, mafia-governed city of Ergastulum, Worick and Nicolas are two "handymen" known as "Benriya" who would take any dirty job from either police or mafia -- for a good price. After an assignment from police the two met and later joined by Alex, a former prostitute who got interested in the mysterious background of the team, in particular of Nicolas' abilities.
Sonya is an assassin attending a normal school. Yasuna is an airhead who follows Sonya around, unaware of how dangerous she is. This adaptation of a 4-panel comic focuses on the adorable ultra-violence that erupts when they try to get along.
Himari Takakura passes away after going out on a trip with her brothers, twins Kanba and Shōma. She was, however, miraculously saved by a spirit in a penguin-shaped hat. In return for her extended life, the twins must search for an item known as the Penguin Drum with the aid of three penguins, which are visible only to the siblings.
Miss Kobayashi is your average office worker who lives a boring life, alone in her small apartment–until she saves the life of a female dragon in distress. The dragon, named Tohru, has the ability to magically transform into an adorable human girl (albeit with horns and a long tail), who will do anything to pay off her debt of gratitude, whether Miss Kobayashi likes it or not.
Junpei Kōsaka is a second-year high school student who despises cats and has an allergy to them. It just so happens that his high school crush is Kaede Mizuno, a girl who adores cats. One day, while walking home from school, Junpei kicks an empty can and unfortunately beans the local neko-jizō-sama (guardian deity of cats). Soon, he finds he can now understand what cats are saying, including his family's own ill-tempered cat, Nyamusasu. However, if he does not grant 100 wishes from cats, he will turn into a cat himself.
At the beginning of the Edo Era, when people enjoyed a time of peace, Lord Tokugawa Tadanaga holds a fighting tournament. In the past, matches were fought with wooden swords. This time, real swords will be used. One-armed Fujiki Gennosuke and blind Irako Seigen will fight each other in this match. Both are disciples of Iwamoto Kogan, who is known as Japan's greatest swordsman. Each of them are determined to prove himself the successor of Iwamoto's school. However, there can only be one champion. So begins a story of intertwining fates, conflict, and strange destinies.
Sotobamura is a small village with around 1300 residents; so small the village isn't even connected to a single highway. An isolated village in which old customs, such as the burial of the dead, are still practiced. One day, the bodies of three people are found dead. Although Ozaki Toshio, the village's lone doctor, feels uncertain, he treats the deaths as a normal occurrence. However, in the days following, the villagers start to die one after the other.
Squid Girl has come to the land from the depths of the sea to conquer humanity for its pollution of the ocean. Unfortunately she ruins the first house she uses as an invasion base and has to work to pay for repairs. Of course, she can't overcome the Aizawa sisters who manage the house, so who knows whether she can subjugate humankind.
Urusei Yatsura is the story of the unluckiest and most lecherous young man alive, Ataru Moroboshi. When aliens decide to invade Earth, Ataru is randomly selected to defend his planet by playing a game of the aliens national sport, tag. Should he win, the world shall be saved. However, Ataru is motivated for far less noble reasons, as the one he plays against is revealed to be the curvaceous alien princess, Lum. The game goes for 10 days, and on the last day, Ataru, motivated by his girlfriend assuring him marriage (and consequently, a marriage night one can assume) should he win, finally catches Lum. However, with his victory he gives a cry of joy for his coming marriage, which is misinterpreted by Lum to be a marriage proposal. She promptly agrees, beginning the two's "marriage" together.