In the year 2071, the Far East is ruled by angry gods. 20 years ago unknown life forms called “Oracle cells” begin their uncontrolled consumption of all life on Earth. Humanity both fears them and reveres them as "aragami." They are immune to all weapons and the mankind's numbers continue to dwindle. The last bastion of hope is the newly developed "God Arcs" weapons that utilize Oracle cells to fight back. The weapons wielders band together into an elite force dubbed "God Eaters."
Enter Sentan, a lush, tranquil island encased in war between the military and those with Hiruko, known as X'amd. On one of these warlike days, Akiyuki Takehara heads off to school and gets caught in a raid by the creatures. Through a series of events he is transformed into a X'amd, and with the help of a Tessikan woman Nakiami along with his highschool friend Haru, Akiyuki is forced to learn to live with the Hiruko or faces the danger of losing his self-control and turn to stone.