In the future, personal computers have developed into "Persocoms", mobile computers that look like human beings. Hideki Motosuwa, a prep school student, desperately wants to buy a Persocom but cannot afford to. One day he finds a Persocom that has been thrown away and decides to keep it. When he turns on the Persocom, all she can say is "Chii" so he decides to name her that. After a while it starts to become apparent that Chii is more than an average Persocom. Having much better performance, it seems that Chii might be a "Chobit", a type of advanced Persocom rumored to have independent thought.
Lain Iwakura appears to be an ordinary girl, with almost no experience with computers. Yet the sudden suicide of a schoolmate, and a number of strange occurrences, conspire to pull Lain into the world of the Wired, where she gradually learns that nothing is what it seems to be... not even Lain herself.
Space Dandy is a space hunter, someone who is paid to search for new, undiscovered alien species. It's an industry where the prize goes to the person who finds aliens the fastest. Dandy searches unknown planets for strange beings with his companions, QT the worn-out robot and Meow from Betelgeuse. Meanwhile, they're being chased by minions of the Gogol Empire, for reasons that are still a mystery.