Two brothers lose their mother to an incurable disease. With the power of "alchemy", they use taboo knowledge to resurrect her. The process fails, and as a toll for using this type of alchemy, the older brother, Edward Elric loses his left leg while the younger brother, Alphonse Elric loses his entire body. To save his brother, Edward sacrifices his right arm and is able to affix his brother's soul to a suit of armor. With the help of a family friend, Edward receives metal limbs - "automail" - to replace his lost ones. With that, Edward vows to search for the Philosopher's Stone to return the brothers to their original bodies, even if it means becoming a "State Alchemist", one who uses his/her alchemy for the military.
GOSICK takes place in 1924 in a small, made-up European country of Sauville. The story centers on Kazuya Kujo, the third son of a Japanese Imperial soldier, who is a transfer student to St. Marguerite Academy, where urban legends and horror stories are all the rage. There he meets Victorique, a mysterious yet beautiful and brilliant girl who never comes to class and spends her days reading the entire content of the library or solving mysteries that even detectives can't solve.
The fictional Japanese city named Sugomori City is built on reclaimed land. But as the years go by, the city's population is decreasing. One day, Sonosaki tells her classmate Katsuhira: "You have been selected to be a Kiznaiver." The Kizuna System, which allows Katsuhira to share his wounds, connects him to the classmates whose lives and personalities completely differ from his. The Kizuna System is an incomplete system for the implementation of world peace that connects people through wounds. All those who are connected to this system are called Kiznaivers. When one Kiznaiver is wounded, the system divides and transmits the wound among the other Kiznaivers.
In a world where dead people turn into books and are stored in the Bantorra Library where anyone who reads a book can learn their past. Bantorra Library is maintained by Armed Librarians who wield psychic powers and their enemy is a religious society known as Sindeki Kyōdan.
Enter Sentan, a lush, tranquil island encased in war between the military and those with Hiruko, known as X'amd. On one of these warlike days, Akiyuki Takehara heads off to school and gets caught in a raid by the creatures. Through a series of events he is transformed into a X'amd, and with the help of a Tessikan woman Nakiami along with his highschool friend Haru, Akiyuki is forced to learn to live with the Hiruko or faces the danger of losing his self-control and turn to stone.