Sakura Kinomoto was an ordinary 4th grader until the day she opened a strange book and let dozens of powerful magic cards loose on the world. Keroberos, the Guardian of the Clow Cards, informs Sakura that it is now her responsibility to find and capture the freed cards. However, much to the reluctant Sakura's dismay, things aren't going to be easy for her. Simply saying magic words and waving her wand around isn't good enough. Each card is a living, thinking, extremely powerful being. She'll have to learn to cope with her new responsibilities, as well as ordinary troubles involving love, school, family, and friends. With the support of her friend Tomoyo and a young boy with powers of his own, she must learn how to use her newly awakened magical abilities to collect each card and prevent the disaster that will befall the world if she doesn't.
In Tokyo, an impenetrable field known as "Hell's Gate" appeared ten years ago. At the same time, psychics who wield paranormal powers at the cost of their conscience also emerged. Hei is one of the most powerful of these psychic agents, and along with his blind associate, Yin, works for one of the many rival agencies vying to unlock the mysteries of Hell's Gate.
Takato Matsuda, Ruki Matsuno, and Lee Jenrya are children who have, by fate, recieved real Digimon, unlike the imaginary ones in the card game they play. Each of the children, or "Digimon Tamers", have their different views on how Digimon should be treated. But when other Digimon begin to appear around Japan, they must put aside their differences to fend off the digital intruders; even though Yamaki, who is the head of a secret organization called Hypnos is trying to eliminate all of the Digimon himself.
Usagi Tsukino was a normal second-year middle school girl whose own life changes one day when she encounters a black cat. The cat's name is Luna who can talk and bears a cresent moon on her forehead. Luna tells Usagi that she is the chosen guardian of justice with the power to transform into Sailor Moon. Usagi now has a new responsiblity which is a mission to find the Illusionary Silver Crystal as well as the other chosen guardians to protect the Moon Princess. During her mission, she must deal with various enemies sent by Queen Beryl who is also after the Illusionary Silver Crystal.