In 2046, people can access a virtual network known as the Neurolinker via their cellphone terminals. A perpetual victim of bullying, middle school student Haruyuki spends his time absorbed in games in a corner of his local network. One day he is approached by the most famous girl in his school, Kuroyukihime (Black Snow Princess). She gives him a strange program called Brain Burst that has the power to "accelerate the world."
Spike Spiegel, a bounty Hunter with a dark past, lives on bounty to bounty, barely making it each time, or not making it at all. His partners Jet Black, Faye Valentine, Ed and Ein the dog all help him in his adventures from planet to planet.
Panty and Stocking—the Anarchy Sisters—are two nasty-ass angels who got booted from the pearly gates for being foul-mouthed bitches! Now they spend their nights blowing up ghosts in the seedy abyss between Heaven and Earth. Panty likes sex, Stocking likes sweets, their afro-sporting main man Garter Belt has a fetish we can't mention. Together, they're turning the mean streets of Daten City into a buffet of bodily fluids. Ghosts don't stand a chance against their lingerie of mass destruction, and if this debaucherous duo can collect enough Heaven Coins, they just might get their halos back. It's a slim chance in hell, but anything can happen when you're rolling commando, especially with Panty and Stocking!